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Search Results for " HMG-CoA Reductase (HMGCR) "

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阻害剤

天然化合物

ライブラリー

カタログ番号	製品名	別名	ターゲット
T14342	Atorvastatin lactone		HMG-CoA Reductase
	Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.		HMG-CoA Reductase
T20765	Atorvastatin		HMG-CoA Reductase , Autophagy
	Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i...		HMG-CoA Reductase , Autophagy
T6450	Clinofibrate	S-8527,Lipoclin	HMG-CoA Reductase , Autophagy
	Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.		HMG-CoA Reductase , Autophagy
T1487	Fluvastatin sodium	XU 62320 sodium,XU-62-320,Fluvastatin sodium salt	Ferroptosis , HMG-CoA Reductase , Autophagy
	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.		Ferroptosis , HMG-CoA Reductase , Autophagy
T6994	SR12813	SR-12813,SR 12813,GW 485801	HMG-CoA Reductase , Autophagy
	SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.		HMG-CoA Reductase , Autophagy
T12092	Monacolin J	Antibiotic MB 530A,Lovastatin diol lactone	HMG-CoA Reductase , Autophagy
	Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.		HMG-CoA Reductase , Autophagy
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T3116	Atorvastatin hemicalcium salt	Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis	Ferroptosis , HMG-CoA Reductase , Autophagy
	Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.		Ferroptosis , HMG-CoA Reductase , Autophagy
T2534	Pitavastatin calcium	P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104	Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T1510	Rosuvastatin calcium	ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.		Potassium Channel , HMG-CoA Reductase , Autophagy
T69006	Atorvastatin lysine
	Atorvastatin lysine is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor.
T21080	(3S,5S)-Atorvastatin	ent-Atorvastatin,3S,5S-Atorvastatin
	ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase).
T11572	HMG499		HMG-CoA Reductase
	HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can eliminate statins-induced accumulation of HMGCR, lower serum cholesterol levels and decrease atherosclerosis [1].		HMG-CoA Reductase
T64292	Simvastatin acid calcium hydrate
	Simvastatin acid (Tenivastatin) calcium hydrate is an orally active inhibitor of HMG-CoA reductase (HMGCR). Simvastatin acid calcium hydrate also inhibits indoxyl sulfate mediated reactive oxygen species (ROS) production...
T63430	Rosuvastatin Sodium
	Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor (IC50: 11 nM) that effectively blocks hERG currents (IC50: 195 nM). Rosuvastatin Sodium reduces the expression of mature hERG and inhibits the inte...

Compounds

Atorvastatin lactone

T14342

Synonym:

Target: HMG-CoA Reductase

Atorvastatin

T20765

Synonym:

Target: HMG-CoA Reductase, Autophagy

Clinofibrate

T6450

Synonym: S-8527,Lipoclin

Target: HMG-CoA Reductase, Autophagy

Fluvastatin sodium

T1487

Synonym: XU 62320 sodium,XU-62-320,Fluvastatin sodium salt

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

SR12813

T6994

Synonym: SR-12813,SR 12813,GW 485801

Target: HMG-CoA Reductase, Autophagy

Monacolin J

T12092

Synonym: Antibiotic MB 530A,Lovastatin diol lactone

Target: HMG-CoA Reductase, Autophagy

Rosuvastatin

T1676

Synonym: ZD 4522

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

Atorvastatin hemicalcium salt

T3116

Synonym: Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Pitavastatin calcium

T2534

Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104

Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Rosuvastatin calcium

T1510

Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium

Target: Potassium Channel, HMG-CoA Reductase, Autophagy

Synonym: ent-Atorvastatin,3S,5S-Atorvastatin

Target:

HMG499

T11572

Synonym:

Target: HMG-CoA Reductase

Simvastatin acid calcium hydrate

カタログ番号	製品名	別名	ターゲット
TN1733	Hesperetin 7-O-glucoside		Anti-infection , Antibacterial , HMG-CoA Reductase
	Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inh...		Anti-infection , Antibacterial , HMG-CoA Reductase
T1207	Lovastatin	MK-803,Mevinolin	Ferroptosis , HMG-CoA Reductase , Autophagy
	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.		Ferroptosis , HMG-CoA Reductase , Autophagy
TN1438	Beta-Amyrin acetate		Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal
	beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
T0683	Mevastatin	Compactin,ML236B	Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
	Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T1664	Meglutol	Dicrotalic acid,3-Hydroxy-3-methylglutaric acid	Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve...		Endogenous Metabolite , HMG-CoA Reductase , Autophagy
T0672	Pravastatin sodium	CS-514 Sodium,CS-514 (sodium)	Ferroptosis , HMG-CoA Reductase , Autophagy
	Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.		Ferroptosis , HMG-CoA Reductase , Autophagy
T0687	Simvastatin	MK-0733,MK 733	Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T75626	Ganoderenic acid K
	Ganoderenic Acid K, isolated from the fruiting bodies of Ganoderma lucidum, exhibits potent inhibitory activity against HMG-CoA reductase (HMGCR), demonstrating an IC50 of 16.5 μM [1].

天然物製品

Hesperetin 7-O-glucoside

TN1733

Synonym:

Target: Anti-infection, Antibacterial, HMG-CoA Reductase

Lovastatin

T1207

Synonym: MK-803,Mevinolin

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

beta-Amyrin acetate

TN1438

Synonym:

Target: Antioxidant, HMG-CoA Reductase, Epoxide Hydrolase, Antifungal

Mevastatin

T0683

Synonym: Compactin,ML236B

Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid

Meglutol

T1664

Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid

Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Pravastatin sodium

T0672

Synonym: CS-514 Sodium,CS-514 (sodium)

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Simvastatin

T0687

Synonym: MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

カタログ番号	製品名
L2510	Lipid Metabolism Compound Library		496 compounds
	A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).

ライブラリー

Lipid Metabolism Compound Library

L2510

Compounds: 496